WASHINGTON, D.C. — August 20, 2026: As extreme heat becomes a growing summer health concern across the United States, doctors are warning that some commonly used medications can make it harder for the body to cope with high temperatures.
The U.S. Centers for Disease Control and Prevention (CDC) says many prescription and over-the-counter medicines can interfere with the body's ability to regulate temperature, sweat normally or maintain proper fluid levels. That can increase the risk of dehydration, heat exhaustion and, in severe cases, heat stroke. (CDC)
How Medications Can Change the Body's Response to Heat
Normally, the human body cools itself through sweating and increased blood flow to the skin. Some medications can interfere with these natural cooling mechanisms.
Diuretics, often known as water pills, can increase fluid loss. Anticholinergic medications may reduce sweating, while certain psychiatric medications can affect temperature regulation. Some blood-pressure medications can also create additional risks during extreme heat. (CDC)
The CDC specifically notes that combinations such as an ACE inhibitor or ARB with a diuretic can increase the risk of harm during hot weather. (CDC)
Common Medication Categories to Watch
People taking certain medications may need to be especially careful during a heatwave. Examples include:
- Diuretics
- Some blood-pressure medications
- Anticholinergic medicines
- Certain psychiatric medications
- Some over-the-counter medications
- Certain cardiovascular medicines
This does not mean people should stop taking prescribed medicines. The CDC advises patients not to change or discontinue medication without first speaking with their healthcare professional. (CDC)
Older Americans May Face Greater Risk
Adults age 65 and older can be particularly vulnerable during extreme heat. The CDC says older adults are more likely to have chronic health conditions and take medications that can affect sweating or the body's ability to control temperature. (CDC)
People with cardiovascular conditions and other chronic illnesses should also have a heat-safety plan and discuss medication-related concerns with their healthcare provider. (CDC)
Warning Signs of Heat Illness
Symptoms of overheating can include heavy sweating, dizziness, headache, weakness, nausea, shortness of breath and muscle cramps. More serious symptoms can indicate heat stroke, which is a medical emergency. (CDC)
If someone becomes confused, loses consciousness or develops signs of severe overheating, emergency medical help should be sought immediately.
What Americans Can Do During a Heatwave
The safest approach is preparation. Stay in air-conditioned locations when temperatures are dangerous, drink fluids according to your healthcare provider's advice, reduce strenuous outdoor activity and monitor yourself for symptoms.
People who take medications that affect fluid balance should ask their doctor or pharmacist what precautions are appropriate for them during extreme heat. This is especially important for people whose doctors have already placed limits on how much fluid they can drink. (CDC)
Important Reminder
Extreme heat can affect medications in another way: some medicines require specific storage temperatures. The CDC advises patients to check medication-storage instructions and avoid leaving medicines in hot cars or other excessively hot locations. (CDC)
The key message is simple: don't stop or alter prescribed medication on your own because of hot weather. Instead, talk with a healthcare professional about creating a personal heat plan before the next major heatwave.

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